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On top of these established recommendations, the ideal macronutrient composition is currently a matter of debate: While the American society highlights uncertainties regarding long-term (histological) endpoints that preclude recommendations in favor of one type over another, a dietary composition in accordance to the Mediterranean dietary (MD) is generally advised by European and Asian societies [6,7,9] given clear signals towards beneficial effects beyond the macronutrient composition (see chapter Mediterranean Diet [MD])

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Vitamin D metabolism, mechanism of action, and clinical applications