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GPX4 inhibitors are senolytic in xenograft models of melanoma and prostate cancer To assess whether GPX4 inhibitors could be used in combination with anticancer therapies in one-two punch approaches 5,6 , we first examined a xenograft model of melanoma in which SK-MEL-103 cells were treated with palbociclib and RSL3, as indicated (Fig

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With high TMAO concentrations, inflammatory signals and cellular damage were observed