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Theoretically, availability of GSH as an intact molecule declines when consumed orally, which could explain why oral glutathione was less effective.16–20 An open-label, single-arm trial study by Handog et al21 used lozenges to prevent absorption by the gastrointestinal tract and found that the melanin index declined significantly in both sun-exposed and unexposed skin.21 Glutathione is likely pivotal for antioxidant defense in melanoma cells