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Introduction Degenerative changes in lumbar intervertebral discs represent a primary driver of persistent lower back pain, creating significant worldwide impact through functional impairment, diminished physical capacity, and substantial medical expenditures [1–2]

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The overexpression of miR-21-3p correlates with the inhibition of critical neuronal and synaptic genes such as DLGAP1 , which decreased the expression of Protocadherin-19 ( PCDH19 ), associated with cognitive impairment