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In the United States alone, the economic burden of PD exceeded $52 billion in 2020, with caregivers losing an average of $19,000 in annual income due to reduced work hours or job loss ( Comparative studies show that while HICs absorb higher per-patient costs through insurance systems and assistive infrastructure, LMICs face a disproportionately higher household-level burden, where out-of-pocket expenses can consume over 50% of monthly income (Figures 4, 5)
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