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GSH is present in all mammalian cells in a constant state of metabolic recirculation (synthesis, degradation, and irreversible loss of GSH), its half-life is 4 days in human erythrocytes, 2 to 4 h in the cytosol of rat hepatic cells and 30 h in the mitochondrial lumen [40,80]

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Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a key nuclear transcription factor for the systemic antioxidant defense system

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