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Gastrointestinal symptoms —including nausea, vomiting, diarrhea, constipation, and abdominal discomfort—are the most frequently reported adverse effects, occurring in 20-30% of patients (varying by dose and population), particularly during dose escalation

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[DOI] [PubMed] [Google Scholar] 71.Arafa M, Agarwal A, Al Said S, Majzoub A, Sharma R, Bjugstad KB, et al