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The positive role of glutathione in preventing hypertension may also be explained by the observations that high glutathione levels prevent platelet-derived growth factor (PDGF)-mediated production of ROS by NADH/NADPH oxidase, which is considered to be the main source of vascular ROS (7), (22)
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Since the patient had an encouraging response to pulsed high dose dapsone therapy, which was well tolerated, without any signs of elevated methemoglobin levels (no significant blue hands, blue lips, shortness of breath) with a recent positive Bartonella FISH test, he was instructed to finish a third pulse of HDDCT with dapsone and PZA
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