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Following administration in animal models: BPC-157 demonstrates rapid systemic distribution within 15-30 minutes of administration TB-500 shows tissue-specific accumulation with preferential uptake in injured areas GHK-Cu exhibits copper-mediated transport and tissue binding characteristics Combined formulation provides both immediate and sustained bioactivity Distribution studies suggest that while each peptide follows distinct pathways, injury sites tend to concentrate all three components, potentially enhancing local therapeutic effects through multiple mechanisms
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Patients with large cartilage knee defects (classified as ≥3cm 2 ) were recruited to a 24-month dual-centre, open-label phase IIB randomised controlled trial (RCT)
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