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the 2 mg start partially mitigated gastrointestinal events (NEJM 2023) Gastrointestinal events were the most common adverse events in every published trial and were mostly mild to moderate in phase 2 (NEJM 2023) No published retatrutide trial reports weight change at 4 weeks Time to onset of side effects is not reported in the phase 2 abstract or in the TRIUMPH press releases Weeks 5-12: Building Momentum Side effects in the trials rose with dose

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doi: 10.3390/toxins13060417