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This is because glutathione performs a cytotoxic and genotoxic inactivation of xenobiotics and consequently promotes detoxification and cellular protection against oxidative stress and additional damage [27]

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It was stated that the cytokines such as TNF-α, IL-1β, IL-6, IL-8, and IL-18 secreted by B lymphocytes and synovial fibroblasts (SFs) potentially regulate the balance of anti-inflammatory and pro-inflammatory factors during arthritis [73,74,75,76,77]

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