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It should be mentioned that in the Liraglutide Effect and Action in Diabetes (LEAD)-6 trial (duration 26 weeks) no difference was observed in estimated geometric mean calcitonin levels between liraglutide 1.8 mg once daily and exenatide 10 μg twice daily [31]
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In contrast, in AMYRs bound to rAmy 15 or the pramlintide analogue, San385 16 , an Asn at the equivalent peptide position (N14 rAmy ) adopts an upward rotamer that is exposed to the solvent environment and forms a H-bond with the backbone of L291 ECL2 (Fig
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