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Through paracrine signaling, MenSCs increase proliferating cell nuclear antigen (PCNA) expression to promote cell proliferation, inhibit caspase-3-mediated apoptosis to reduce cell death, increase the secretion of anti-inflammatory factors such as IL-10 and keratinocyte growth factor (KGF), and simultaneously suppress proinflammatory cytokines such as IL-1β, neutrophil infiltration, and myeloperoxidase (MPO) activity, thereby attenuating pulmonary inflammation and restoring lung function
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However, a drawback of the iron load estimation by this method is that the distribution and concentration of iron in liver and spleen biopsy samples is not uniform (Figure 3e,f) [104]