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Principal component analysis (PCA) showed that a subset of knockdown samples separated clearly from the control, reflecting substantial transcriptional changes upon Myb protein depletion, while other knockdown samples displayed a more subtle divergence (Fig

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The latter enrolled 190 patients with obesity (mean age 54.4 years, mean BMI 36.1 kg/m 2 ) and biopsy-proven MASH and moderate-to-severe fibrosis regardless of the presence of T2D, showing a BW reduction of 10.7%, 13.3%, 15.6% and 0.8% at 52 weeks with tirzepatide 5 mg, 10 mg, 15 mg and placebo, respectively 39