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Mutations of two transmembrane segments in GluN1 and GluN2A subunits (F639A and A85W, respectively) significantly reduce the sensitivity of recombinant NMDA receptors to halothane, isoflurane, cyclopropane and xenon, but have no effects on their sensitivity to ketamine or nitrous oxide, indicating that the mechanisms of inhibition of NMDA receptors among various anesthetics may differ [256]

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Zhang H, Deng T, Liu R, Ning T, Yang H, Liu D