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They found that histamine selectively upregulated the expression of H 1 , H 2 , and H 3 receptors, stimulated the synthesis of astrocytic GDNF and inhibited the production of pro-inflammatory cytokines, TNF-α and IL-1β in a concentration-dependent manner
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The most common adverse effects are mild injection site reactions including temporary redness, swelling, or discomfort that resolve within 24-48 hours
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