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8,9 However, despite restoring perfusion, these procedures frequently trigger ischemia–reperfusion (I/R) injury, in which reperfusion exacerbates oxidative stress, inflammation, endothelial dysfunction, and cell death, ultimately compromising therapeutic outcomes

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The copper ion binds to the peptide through a square-planar pyramid configuration, creating an extraordinarily stable complex with a binding affinity (pK = 16.44) approximately 10 million times higher than other tripeptides